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MabSelect™ VL resin in ReadyToProcess™ columns
ReadyToProcess™ MabSelect™ VL NS, 32 L (450/200)
MabSelect™ VL protein L resin for affinity capture of antibody Fabs and bispecifics containing kappa light chain in ReadyToProcess™ columns.
| Chromatography technique | Antibody affinity chromatography |
| Application | For manufacturing of biopharmaceuticals for clinical phase I, II, and III studies. Depending on the scale of operations, the column can also be used for full-scale manufacturing, as well as for preclinical studies. |
| Bed dimensions | 450 × 200 mm |
| Bed height | 200 mm |
| Bed volume | 32 L |
| Certificate of Analysis | Yes |
| Column i.d. | 450 mm |
| Pressure max. (over the packed bed during operation) | 2 bar (0.2 MPa, 29 psi) |
| Storage | 2˚C to 8˚C, 20% ethanol |
产品详情
Prepacked ReadyToProcess™ columns with MabSelect™ VL protein L resin. The redesigned protein L ligand provides high binding capacity and improved alkaline stability. For affinity capture of antibody Fabs, bispecifics, and other variants containing a kappa light chain. MabSelect™ VL in ReadyToProcess™ columns is supplied made to order in 80 mm, 126 mm, 178 mm, 251 mm, 359 mm, and 450 mm column diameter sizes in different bed heights.
- High dynamic binding capacity protein L resin for efficient capture of antibody Fabs, bispecifics, and variants containing a kappa light chain.
- Stable when cleaned with 0.1 M NaOH, reducing risk for bioburden incidents.
- Provides good resolution for product-related impurities in the capture of bispecific antibodies.
- ReadyToProcess™ columns with robust design and validated column packing methods for consistent performance.
Built for a diversifying pipeline
As the diversity of antibody variants increases, so does the need for chromatography resins that can capture and purify these variants. As an alternative to protein A, protein L resin can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1.
