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These 96-well filter plates are prefilled with Capto™ Phenyl ImpRes hydrophobic interaction chromatography (HIC) resin for use in high-throughput process development workflows.
- Allow parallel screening of chromatographic conditions
- Allows fast and efficient evaluation of parameters for binding, wash, and elution conditions
- Prefilled with Capto™ Phenyl ImpRes HIC polishing resin
- Can be used manually or with automated robotic systems
About PreDictor™ plates for high-throughput process development
PreDictor™ plates are single-use, 96-well filter plates for parallel screening of resins and chromatographic conditions.
Data generated using PreDictor™ plates shows good correlation with data from chromatography columns, making the plates an excellent tool for initial screening. The plates can be used with a robotic system or operated manually with a multichannel pipet (using vacuum or centrifugation).
Learn how our PreDictor™ plates can be used for developing HIC steps:
- Step-by-step HTPD workflow to optimize an HIC step
- Developing an HIC polishing step for removal of mAb aggregates
Be sure to download Assist software to support the PreDictor™ plate workflow from setup of experimental design to data evaluation.
Capto™ Phenyl ImpRes – a high-resolution HIC resin
Capto™ Phenyl ImpRes resin is an HIC resin with phenyl ligand for the intermediate and polishing steps in a downstream purification process for monoclonal antibodies (mAbs), mAb variants, and other biomolecules. It delivers high resolution while maintaining excellent pressure-flow properties, achieved by combining the high-flow characteristics of Capto™ resin with a small particle size.
Not sure which HIC resin you should use? We recommend starting with one of the kits below:
- PreDictor™ Capto™ HIC screening kit, a set of 96-well plates prefilled with six Capto™ hydrophobic interaction chromatography resins for use in high-throughput process development (HTPD)
- HiTrap™ Capto™ HIC selection kit, a set of five Capto™ HIC resins in HiTrap™ columns for resin selection and condition screening
Capto™ Phenyl ImpRes resin is available in other formats (Fig 1):
- Bulk resin bottles and containers of Capto™ Phenyl ImpRes resin for column packing
- PreDictor™ Capto™ Phenyl ImpRes RoboColumn™ units, miniaturized columns for HTPD
- HiTrap™ Capto™ Phenyl ImpRes 1 mL and 5 mL columns for easy use with a syringe, peristaltic pump, or chromatography system
- HiScreen™ Capto™ Phenyl ImpRes columns optimized for method and process development
- ReadyToProcess™ Capto™ Phenyl ImpRes columns, in various sizes for scale-up and GMP manufacturing
- Process Characterization Kit Capto™ Phenyl ImpRes, designed for studying the potential impact that resin ligand density might have on the process outcome
Fig 1. Prepacked chromatography formats available from Cytiva to support various scales, from screening to GMP manufacturing.
