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1.Cleaning procedures for ÄKTAprocess system external surfaces
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分类:线上应用课程, 线上专题课程 – 重组蛋白基础课堂
课程分类:线上应用课程, 线上专题课程 – 重组蛋白基础课堂
复杂的生物药制品 ( 例如高抗体浓度和高粘度的产品 ) 通常需要比期望体积更大的过滤器,因过滤器及系统死体积的增加,而导致产品损失增加。Supor ® Prime 除菌级过滤器现已开发出来,可以有效减少这一问题的影响。
Powdered activated carbon (PAC) is widely used in the pharmaceutical industry for decolorization and removal of other trace impurities. The use of bulk PAC has significant drawbacks relating to the handling of bulk carbon powder, cleaning of process equipment, and time (costs) associated with carbon removal from the process. Seitz AKS immobilized carbon media alleviates these concerns by incorporating activated carbon within a matrix of cellulosic fibers.
Seitz™ P-series depth filter sheets were specifically developed for the strict requirements in the biotech and pharmaceutical industries. Manufactured with stringent in-process control methods, they facilitate consistent filtration quality, enable a high purity of filter medium, and align with the requirements of the pharmaceutical industry.
‘Emflon II’ is an outstanding filter medium from Pall, designed specially for air and gas filtration for total removal of particles as fine as 0.01 μm and contaminating bacteria and bacteriophage.
Profile II filter cartridges are designed for high-performance clarification and particle removal in food and beverage processes.
With the ever-present risk of virus contamination in biologic products, potential sources of virus contamination of biotechnology products include viruses associated with cell lines (endogenous viruses), or viruses introduced into the cell line or product from culture medium or during the production process (adventitious viruses).
The NovasipTM DV50 filter capsule is a disposable, pharmaceutically rated Junior style steamable filter incorporating an Ultipor® VF grade DV50 pleated mem- brane element for removal of viruses 40-50 nm and larger. The Novasip DV50 capsule filter is supplied non-sterile. It can also be gamma irradiated1.
Pall Kleenpak capsule filters with intrinsically hydrophilic positive zeta potential Posidyne membrane are rugged, self-contained sanitary filters designed for small-batch sterile filtration of aqueous pharmaceutical solutions. With a net positive charge in most aqueous solutions from pH 3 to 10, Kleenpak Capsules with Posidyne Membrane Assemblies can be effective in removing contaminants such as cell debris and endotoxin smaller than the filter rating.