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- Allow parallel screening of chromatographic conditions
- Allow fast and efficient evaluation of parameters for binding, wash, and elution conditions
- Prefilled with Capto™ Butyl ImpRes HIC polishing resin
- Can be used manually or with automated robotic systems
About PreDictor™ plates for high-throughput process development
PreDictor™ plates are single-use, 96-well filter plates for parallel screening of resins and chromatographic conditions.
Data generated using PreDictor™ plates show good correlation with data from chromatography columns, making the plates an excellent tool for initial screening. The plates can be used with a robotic system or operated manually with a multichannel pipet (using vacuum or centrifugation).
Learn how our PreDictor™ plates can be used for developing HIC steps:
- Step-by-step HTPD workflow to optimize an HIC step
- Developing an HIC polishing step for removal of mAb aggregates
Be sure to download Assist software to support the PreDictor™ plate workflow from setup of experimental design to data evaluation.
Capto™ Butyl ImpRes – a high-resolution HIC resin
Capto™ Butyl ImpRes HIC resin has a butyl ligand for intermediate and polishing steps in a downstream purification process for monoclonal antibodies (mAbs), mAb variants, and other biomolecules. It delivers high resolution while maintaining excellent pressure-flow properties, achieved by combining the high-flow characteristics of Capto™ resin with a small particle size.
Not sure which HIC resin you should use? We recommend starting with one of the kits below:
- PreDictor™ Capto™ HIC screening kit, a set of 96-well plates prefilled with six Capto™ hydrophobic interaction chromatography resins for use in high-throughput process development (HTPD)
- HiTrap™ Capto™ HIC selection kit, a set of five Capto™ HIC resins in HiTrap™ columns for resin selection and condition screening
Capto™ Butyl ImpRes resin is available in other formats (Figure 1):
- Bulk resin bottles and containers of Capto™ Butyl ImpRes resin for column packing
- PreDictor™ Capto™ Butyl ImpRes RoboColumn™ units, miniaturized columns for HTPD
- HiTrap™ Capto™ Butyl ImpRes 1 mL and 5 mL columns for easy use with a syringe, peristaltic pump, or chromatography system
- HiScreen™ Capto™ Butyl ImpRes columns optimized for method and process development
- ReadyToProcess™ Capto™ Butyl ImpRes columns, in various sizes for scale-up and GMP manufacturing
- Process Characterization Kit Capto™ Butyl ImpRes, designed for studying the potential impact of resin ligand density on the process outcome
Fig 1. Prepacked chromatography formats available from Cytiva to support various scales, from screening to GMP manufacturing.
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