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Biacore™ 4000 表面等离子共振系统

Biacore 4000
Biacore™ 4000 已停产,并替换为 Biacore™ 8 系列。 将于 2024 年 8 月 31 日停止为 Biacore™ 4000 提供维护服务。在此之后,能否继续提供维护服务将取决于我们的供应商是否备有可用零件。

停产,可选替代产品
Biacore 8K

产品规格
Biacore 4000

 

Additional Packages Antibody extension, LMW extension
Affinity range fM to mM
Analysis temperature 4°C to 40°C
Application Kinetics/affinity characterization, kinetics/affinity screening, LMW interaction analysis, fragment screening, epitope mapping, immunogenicity*, concentration analysis.
Association Rate (ka) (proteins) 103 to 109 M-1s-1
Baseline drift < 0.3 RU/min in ambient temperature range 15°C to 35°C
Baseline noise < 0.1 RU (RMS)
Concentration range 2 pM to 2 mM
Data Collection Rate 1 or 10 Hz
Data Evaluation Time 120 curve sets < 6 min
Detection technology Surface plasmon resonance (SPR) biosensor
Dissociation Rate (kd) 5 × 10-5 to 1 s-1
Footnote * The application can be performed with limitations in software and/or hardware functionality
GxP Support Yes (included)
Immobilized Interactant Consumption 3 – 10 µg per immobilized spot
Immobilized Molecule Consumption 3 to 10 μg/spot
Includes Biacore 4000 includes a processing unit, control and evaluation software, Windows operating system, barcode scanner and a dedicated trolley for the processing unit and thermostat unit. The computer and the external thermostat unit for reliable temperature control of sample compartment are ordered seperately.
Molecular Weight Limit > Mr 50
Number of flow cells 4 × 5 spots
Precision (concentration analysis) <5% CV
Sample Capacity Antibodies: 10 × 96, LMW: 6 × 384
Sample storage temperature 4°C to 40°C
Sample Volume (kinetics) 28 to 376 μL
Unattended Run Time 60 h
高通量 SPR 系统可提供高质量的相互作用数据,从而在抗体选择、药物发现等方面做出更明智的决策。
  • 高灵敏度
  • 60 小时无人值守运行,可并行多达分析 16 个靶点。
  • 大规模分子分析在 24 小时内产生多达 4800 种相互作用。
  • 创新软件解决方案可提高生产率和性能。

Biacore™ 4000 包括

主机、控制和分析软件、Windows 操作系统、条形码扫描仪以及用于主机和恒温器单元的专用推车。计算机和用于可靠控制样品室温度的外部恒温器单元需单独订购。